SWEAT GLUCOSE SENSORS AND COLLECTION DEVICES FOR GLUCOSE MEASUREMENT

摘要

A sweat glucose sensor for determining the glucose concentration in a volume of sweat is disclosed. The sweat glucose sensor may comprise two or more electrodes in contact with sweat in a container defined by two or more layers of a skin patch. The container may additionally contain a glucose enzyme that reacts with glucose in sweat collected by the container. The reaction of the glucose in the sweat with the glucose enzyme may affect an electrical signal passed by the two or more electrodes. The electrical signal may then be used to determine a sweat glucose concentration. The sweat glucose sensor may comprise two or more fill electrodes, also positioned to contact sweat collected by the container. The fill electrodes may be used, for example, to determine whether the skin patch contains a requisite volume of sweat to perform an accurate glucose measurement. Devices, methods, and kits for collecting sweat that has come to a skin surface are also disclosed.