Antibodies to MAdCAM

摘要

Description of antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. Furthermore, description of antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins, and isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. Description of methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment, including gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. Description of transgenic animals or plants comprising the present nucleic acid molecules.