| 发明名称 |
Peptidyl prodrugs and linkers and stabilizers useful therefor |
| 摘要 |
The present invention provides analogues of duocarmycins that are potent cytotoxins. Also provided are peptidyl and disulfide linkers that are cleaved in vivo. The linkers are of use in forming prodrugs and conjugates of the cytotoxins of the invention as well as other diagnostic and therapeutic moieties. The invention provides prodrugs and conjugates of the duocarmycin analogues with the linker arms of the invention.
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| 申请公布号 |
USRE41252(E1) |
申请公布日期 |
2010.04.20 |
| 申请号 |
US20080126731 |
申请日期 |
2008.05.23 |
| 申请人 |
MEDAREX, INC. |
发明人 |
NG HOWARD P.;MCGEE DANNY P. C.;WU GUOXIAN;MOORE JIMMIE;LI ZHI-HONG;GANGWAR SANJEEV;SAUNDER OLIVER L.;ASTAFIEVA IRINA;MARTICHONOK VALERI |
| 分类号 |
A61K31/535;A61K31/343;A61K31/403;A61K31/407;A61K31/4439;A61K31/454;A61K31/4545;A61K31/496;A61K38/00;A61K39/395;A61K47/48;A61P35/00;A61P43/00;C07D405/06;C07D405/12;C07D405/14;C07D417/04;C07D417/14;C07D487/02;C07D487/04;C07D487/10;C07D521/00;C07F7/18;C07F9/6561;C07K5/02;C07K7/02;C07K7/06 |
主分类号 |
A61K31/535 |
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