发明名称 |
Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors |
摘要 |
The present invention provides novel materials and screening methods for identifying agonists and antagonists of cell receptors. Methods are disclosed for identifying agonists and antagonists using chimeric receptors comprising the extracellular ligand-binding domain of a first receptor fused with the transmembrane and intracellular domains of a second receptor containing an intracellular immunoreceptor tyrosine-based activation motif (ITAM).
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申请公布号 |
US7700728(B2) |
申请公布日期 |
2010.04.20 |
申请号 |
US20060388884 |
申请日期 |
2006.03.24 |
申请人 |
SCHERING CORPORATION |
发明人 |
BATES ELIZABETH ESTHER MARY;MERCK ESTELLE;DE BOUTEILLER ODETTE;CAUX CHRISTOPHE |
分类号 |
C07K14/00;A61K38/16 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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