| 发明名称 |
REGULATION OF NEUROTRANSMITTERS SEQUESTRATION AND RELEASE THROUGH MANIPULATION OF THE VESICULAR FUNCTIONS |
| 摘要 |
A method of selecting an agent comprising a neuroprotecting activity is disclosed. The method comprises: (a) introducing a plurality of agents into a plurality of cells; and (b) analyzing Vesicular Monoamine Transporter 2 (VMAT2) transcription in the cells; and (c) identifying an agent of the plurality of agents capable of up-regulating DJ-1-dependent VMAT2 transcription in the cells, thereby selecting the agent comprising the neuroprotectingactivity.
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| 申请公布号 |
US2010093600(A1) |
申请公布日期 |
2010.04.15 |
| 申请号 |
US20080450076 |
申请日期 |
2008.03.12 |
| 申请人 |
RAMOT AT TEL AVIV UNIVERSITY LTD. |
发明人 |
LEV NIRIT;OFFEN DANIEL;MELAMED ELDAD |
| 分类号 |
C12Q1/02;A61K31/711;A61K38/02;C07K2/00;C07K7/06;C07K7/08;C07K14/00;C12N5/00;C12N15/11;C12Q1/68 |
主分类号 |
C12Q1/02 |
| 代理机构 |
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