A method of titration using a combination continuous flow and pulse flow portable oxygen concentration system (system) with a patient includes: a) providing the system in a continuous flow mode and titrating the patient to a predetermined blood oxygen saturation using the system at one or more predetermined conditions in the continuous flow mode; b) providing the system in a pulse flow mode and titrating the patient to the same predetermined blood oxygen saturation as step a using the system at the same one or more predetermined conditions as in step a in the pulse flow mode; c) determining an Individualized Pulse Dose Equivalent (IPDE) correlation based on data obtained from steps a and b; d) providing the system with the IPDE correlation; and e) using the IPDE correlation to operate the concentrator in a more efficient manner.
