FAST-ACTING REGULAR SOLID DISPERSION COMPRISING AN EXTRACT OF SALVIA MILTIORRHIZA, THE ORAL FORMULATION COMPRISING THE SAME AND THE PREPARATION METHOD THEREOF

摘要

PURPOSE: A rapid effective solid dispersion of Salvia miltiorrhiza extract and oral formulation containing the same are provided to improve solubility, stability and release rate. CONSTITUTION: A rapid effective solid dispersion contains Salvia miltiorrhiza extract and polyxyethylenepolyoxypropylene-polyoxyethylene copolymer. Salvia miltiorrhiza extract contains 40-90 weight% of Cryptotanshinone, tanshinone I or tanshinone IIA. The Salvia miltiorrhiza extract is isolated using water, methanole, ethanol and butanol. A rapid effective oral formulation comprises a solid dispersion of the Salvia miltiorrhiza extract and polyoxyethylene-polyoxypropylene-polyoxyethylene copolymer, and pharmaceutically acceptable oral carrier or excipient.