发明名称 |
FUNCTIONAL ANTAGONISTS OF HEDGEHOG ACTIVITY |
摘要 |
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the funtional antagonists are also described.
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申请公布号 |
CA2348773(C) |
申请公布日期 |
2010.04.13 |
申请号 |
CA19992348773 |
申请日期 |
1999.11.02 |
申请人 |
BIOGEN, INC. |
发明人 |
WILLIAMS, KEVIN;RAYHORN, PAUL;GARBER, ELLEN A.;PEPINSKY, BLAKE R. |
分类号 |
C12N15/09;C12N15/12;A61K38/00;A61P35/00;A61P43/00;C07K14/435;C07K14/46;C07K14/47;C07K14/705;C07K17/08;C07K17/12;C07K19/00;C12N1/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/00;C12Q1/42 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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