CHIMERIC NATRIURETIC POLYPEPTIDES AND METHODS FOR INHIBITING CARDIAC REMODELING
摘要
Materials and methods related to chimeric polypeptides containing the amino acid sequence of CNP and the C-terminal sequence of DNP. The polypeptides are natriuretic and diuretic, GFR enhancing, cardiac unloading, renin inhibiting and less hypotensive when compared to BNP. The polypeptides also inhibit cardiac fibroblast proliferation.
申请公布号
WO2009149161(A9)
申请公布日期
2010.04.08
申请号
WO2009US46095
申请日期
2009.06.03
申请人
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;BURNETT, JOHN, C.;CHEN, HORNG, H.;LISY, ONDREJ