METHODS FOR THE TREATMENT OF GRAFT-VERSUS-HOST DISEASE
摘要
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.
申请公布号
WO2010040096(A2)
申请公布日期
2010.04.08
申请号
WO2009US59437
申请日期
2009.10.02
申请人
EMORY UNIVERSITY;HOSSAIN, MOHAMMAD, S.;GEWITZ, ANDREW, T.;ROBACK, JOHN, D.;WALLER, EDMUND, K.
发明人
HOSSAIN, MOHAMMAD, S.;GEWITZ, ANDREW, T.;ROBACK, JOHN, D.;WALLER, EDMUND, K.