发明名称 |
PROCESS FOR THE SYNTHESIS OF IB-MECA |
摘要 |
The present disclosure provides a method for the synthesis of IB-MECA. More specifically, the present disclosure provides a simple and high yield method for Good Manufacturing Production (GMP) of IB-MECA. The method involves the reaction of 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine-9-riboside with a diol protecting reagent; oxidation of the primary alcohol in the diol protected 6-halopurine; reaction of the diol protected 6-halopurine with a nucleophile (e.g. methylamine); substitution of the halogen group with iodobenzylamine and removal of the diol protecting group.
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申请公布号 |
US2010087636(A1) |
申请公布日期 |
2010.04.08 |
申请号 |
US20080450094 |
申请日期 |
2008.03.13 |
申请人 |
BRUZINSKI PAUL;LIU XUEJUN;GIBB CAMERON;HERNANDEZ-ABAD PEDRO E |
发明人 |
BRUZINSKI PAUL;LIU XUEJUN;GIBB CAMERON;HERNANDEZ-ABAD PEDRO E. |
分类号 |
C07H19/16;C07H1/00 |
主分类号 |
C07H19/16 |
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