COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOF

摘要

This invention provides recombinant polypeptides comprising listeriolysin fused to an antigen such as a fragment of a High Molecular Weight Melanoma- Associated Antigen (HMW- MAA), recombinant Listeria strains comprising same, and methods of inducing an anti-HMW- MAA and anti HER-2/neu immune response thus treating and impeding the growth of tumors, comprising administering same.