发明名称 |
INFLUENZA INHIBITING COMPOSITIONS AND METHODS |
摘要 |
The present invention provides peptides, peptide analogs, peptide derivatives and pharmaceutical compositions useful for treating or preventing influenza infections or preventing the person-to-person transmission of an influenza infection. A peptide of the invention comprises an influenza virus-cell fusion inhibiting portion of the fusion initiation region (FIR) of a wild-type influenza hemagglutinin 2 protein or a variant thereof. In a preferred embodiment, a peptide of the invention consists of 8 to 40 consecutive amino acid residues a portion of a wild-type influenza hemagglutinin 2 protein or a variant thereof, the portion of the protein comprising the FIR of the protein and up to five amino acid residues on the amino-terminal and carboxy-terminal sides of the FIR. |
申请公布号 |
EP2170365(A1) |
申请公布日期 |
2010.04.07 |
申请号 |
EP20080779763 |
申请日期 |
2008.06.25 |
申请人 |
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;AUTOIMMUNE TECHNOLOGIES, LLC |
发明人 |
GARRY, ROBERT F.;WILSON, RUSSELL B. |
分类号 |
A61K38/00;C07K2/00;C07K14/11 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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