发明名称 |
DENDRIMER CONJUGATES OF AGONISTS AND ANTAGONISTS OF THE GPCR SUPERFAMILY |
摘要 |
<p>Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an A1 adenosine receptor agonist having a purine nucleoside moiety and a functional group at the N6 position of the purine nucleoside moiety, wherein the functional group has the formula (I): N6H—Ar1—CH2—C(═O)NH—R1 (I), wherein Ar1 and R1 as defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.</p> |
申请公布号 |
EP2170401(A1) |
申请公布日期 |
2010.04.07 |
申请号 |
EP20080771603 |
申请日期 |
2008.06.20 |
申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;INSERM |
发明人 |
JACOBSON, KENNETH A.;KIM, YOONKYUNG;KLUTZ, ATHENA;HECHLER, BEATRICE;GACHET, CHRISTIAN |
分类号 |
A61K47/48;A61K49/00;A61P1/00;A61P9/00;A61P13/00;A61P25/00;A61P29/00;A61P31/00;A61P35/00 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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