HIGHLY AQUEOUS LIQUID CARRIER FORMULATIONS

摘要

Disclosed is a liquid carrier vehicle for a dissolved or suspended pharmaceutically active agent administered to a patient via inhalation of an aerosol where the aerosol is produced by an electrohydrodynamic spraying device and where the liquid carrier vehicle comprises: a. from about 50% V/V to about 100% V/V water; b. from about 0% to about 40% V/V ethanol; c. from about 0% to about 30% V/V of a co-solvent; d. from about 0.5% to about 10% V /V of a pharmaceutically acceptable excipient; and e. from about 0.05% W/V to about 10% W/V of a derivatized carbohydrate surfactant; wherein said liquid carrier has a resistivity of from about 25ohm m to about 8000 ohm m and a surface tension of from about 20 dyne/cm to about 40 dyne/cm. Also disclosed are liquid compositions comprising the liquid carrier vehicle containing a dissolved or suspended pharmaceutically active agent as well as a method of treating a patient using such liquid compositions.