摘要 |
<P>PROBLEM TO BE SOLVED: To provide a composition for the sustained expression of such an osteogenic therapeutic protein that performs bone generation at the bone defect site by leading an efficient regeneration of bone. <P>SOLUTION: This invention discloses a composition for making bone at a bone defect site for a patient suffering from low bone mass, which includes inserting a gene encoding a protein having bone regenerating function into a connective tissue cell operably linked to a promoter, and transplanting the mammalian cell into the bone defect site, and allowing the bone defect site to make the bone. <P>COPYRIGHT: (C)2010,JPO&INPIT |