发明名称 METHOD FOR PRODUCING TRIAZOLE DERIVATIVE
摘要 <p>Provided is a method whereby a triazole derivative having a (1,3-dioxan-5-yl)thio group of improved qualities can be produced at an elevated yield by using an industrially more advantageous operation while reducing impact on the environment.  Also provided is a triazole derivative having a high purity. Sodium hydroxide or sodium ethoxide is used in a reaction between an epoxide and a thioester.  Hydrochloride of a diol compound is reacted with an aldehyde in the presence of trimethylsilyl chloride together with an organic base and in the presence or absence of an alcohol.  Further, sodium methoxide is used in a coupling reaction between a phosphonic acid ester and an aldehyde.</p>
申请公布号 WO2010035766(A1) 申请公布日期 2010.04.01
申请号 WO2009JP66583 申请日期 2009.09.25
申请人 DAIICHI SANKYO COMPANY, LIMITED;KISHI, NAOYUKI;IKEUCHI, YUTAKA;SAITO, TOMONORI;HARA, MANABU;TAKAHASHI, OSAMU 发明人 KISHI, NAOYUKI;IKEUCHI, YUTAKA;SAITO, TOMONORI;HARA, MANABU;TAKAHASHI, OSAMU
分类号 C07D405/12;A61K31/4196;A61P31/10;C07C253/30;C07C255/56 主分类号 C07D405/12
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