HIGH-BIOAVAILABILITY PARTICLE COATED WITH FUNGICIDE AND POLYMER

摘要

THE PRESENT INVENTION DISCLOSES A HIGH-BIOAVAILABILITY PARTICLE COATED WITH FUNGICIDE AND POLYMER, WHICH MAINLY COMPRISES: (A) A COATING LAYER INCLUDING FUNGICIDE, A POLYMER, AN ACIDIC SUBSTANCE, TALC, A BONDING AGENT, ETHANOL AND DICHLOROMETHANE; (B) AN ANTICOAGULANT LAYER INCLUDING TALC, HYDROXYPROPYL METHYLCELLULOSE (HPMC) AND A PLASTICIZER; AND (C) A PAT.1ICULATE CORE HAVING A DIAMETER RANGING FROM 300µmTO 500µm (3050 MESH). IN THE PRESENT INVENTION, THE TALC IS ADDED TO PREVENT THE PARTICULATE CORES FROM AGGREGATING. IN ADDITION, THE PARTICULATE CORES ARE SMALL-SIZED ENOUGH AND THE POLYMER AND THE ACIDIC SUBSTANCE ARE ADDED TO THE COATING LAYER, SO THAT SOLUBILITY IS INCREASED AND BIOAVAILABILITY IS THUS IMPROVED.