发明名称 |
Process for production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-oxo-2-substituted-2,3-dihydro-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionate ester and intermediate for the process |
摘要 |
Disclosed is a production process using, as an intermediate, a 6-(halomethyl)-1,2-benzisooxazol-3(2H)-one derivative represented by the general formula: Wherein R<5> represents a methyl group substituted by at least one phenyl group which may be substituted, or an oxygenated heterocyclic ring which may be substituted; and X represents a halogen atom. The process is useful for the production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-benzisoxazol-6-yl)methoxy]phenyl]propionic acid, which is useful as an antirheumatic agent, in a high yield and in a safe and simple manner. |
申请公布号 |
ZA200807190(B) |
申请公布日期 |
2010.03.31 |
申请号 |
ZA20080007190 |
申请日期 |
2007.02.19 |
申请人 |
TOYAMA CHEMICAL CO., LTD. |
发明人 |
YONEZAWA, KENJI;TAKAMATSU, TAMOTSU;AOKI, NAOKATU;HASHIMOTO, TOMOHIRO;TAKEBAYASHI, MASAHIRO;SUZUKI, YOSHIAKI;OONISHI, YUJI |
分类号 |
C07B;C07C;C07D |
主分类号 |
C07B |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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