发明名称 |
Method of manufacturing labelled oligonucleotide conjugates |
摘要 |
The present invention relates to a method for the manufacture of labeled oligonucleotide conjugates comprising the reaction of (a) an oligonucleotide having a labile protecting group bound to a terminal hydroxy group, and (b) a labeling compound, wherein said labile protecting group is partially or completely substituted by said labeling compound in a nucleophilic substitution reaction.
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申请公布号 |
US7687618(B2) |
申请公布日期 |
2010.03.30 |
申请号 |
US20050531292 |
申请日期 |
2005.11.21 |
申请人 |
NIMBLEGEN SYSTEMS GMBH |
发明人 |
STENGELE KLAUS PETER;KVASSIOUK EVGUENI |
分类号 |
C07H21/00;C07H19/04;C07H21/02;C12Q1/68 |
主分类号 |
C07H21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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