| 发明名称 |
Oligonucleotides with alternating segments of locked and non-locked nucleotides |
| 摘要 |
The present invention is directed to novel oligonucleotides with improved antisense properties. The novel oligonucleotides comprise at least one Locked Nucleic Acid (LNA) selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides. The present invention also provides a new class of pharmaceuticals which comprise antisense oligonucleotides and are useful in antisense therapy.
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| 申请公布号 |
US7687617(B2) |
申请公布日期 |
2010.03.30 |
| 申请号 |
US20030717434 |
申请日期 |
2003.11.18 |
| 申请人 |
SANTARIS PHARMA A/S |
发明人 |
THRUE CHARLOTTE ALBAEK;ROSENBOHM CHRISTOPH;HANSEN HENRIK FRYDENLUND;WESTERGAARD MAJKEN;MIKKELSEN NIKOLAJ DAM;CHRISTENSEN SIGNE M.;KOCH TROELS;PEDERSEN DANIEL SEJER;FRIEDEN MIRIAM |
| 分类号 |
C07H21/04;A61K31/70;A61K31/7088;C07H21/00;C12N15/11 |
主分类号 |
C07H21/04 |
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