| 摘要 |
L-Proline is prepared by culturing an auxotrophic mutant of Brevibacterium flavum requiring at least one of the amino acids isoleucine, ornithine, citrulline, arginine or histidine for growth under aerobic conditions at a pH of between 5.5 and 8.0 in an aqueous culture medium containing an assimilable carbon source, an assimilable nitrogen source, optional growth promoting agents and at least one of the amino acids isoleucine, ornithine, citrulline, arginine and histidine. Preferred mutants are Brevibacterium flavum A.T.C.C. Nos. 15940-2.
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