发明名称 |
PROCESS FOR PREPARING ALPHA AMINOACETALS IN RECEMIC FORM |
摘要 |
<p>The invention relates to a process for preparing an a-aminoacetal, or addition salts thereof, of formula (I) in recemic form comprising the steps consisting in: reacting a glyoxal monoacetal of formula (II) with an arylalkylamine of formula (III) in such a way as to obtain an imine of formula (IV); adding a Grignard reagent of formula R3-Mg-HaI to said imine of formula (IV) so as to obtain an amine of formula (V), and - deprotecting the amine of formula (V) in such a way as to obtain the compound of formula (I) in racemic form, and, where appropriate, adding an inorganic or organic acid in order to obtain an addition salt of the a-aminoacetal of formula (I).</p> |
申请公布号 |
WO2010031544(A1) |
申请公布日期 |
2010.03.25 |
申请号 |
WO2009EP06695 |
申请日期 |
2009.09.16 |
申请人 |
CLARIANT SPECIALTY FINE CHEMICALS (FRANCE);ALBALAT, MURIEL;PRIMAZOT, GERALDINE;VALLEJOS, JEAN-CLAUDE;WILHELM, DIDIER |
发明人 |
ALBALAT, MURIEL;PRIMAZOT, GERALDINE;VALLEJOS, JEAN-CLAUDE;WILHELM, DIDIER |
分类号 |
C07C209/66;C07C211/03;C07C211/17;C07C211/27;C07C213/02 |
主分类号 |
C07C209/66 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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