发明名称 |
ANIMAL HAVING MODIFICATION IN MGAT2 GENE |
摘要 |
It is an object to provide a gene-modified non-human animal having inactivated MGAT2 gene and a gene-modified non-human animal cell, which are useful for the search of the function of MGAT2 in vivo. It is another object to provide a method for screening of a compound capable of inhibiting the activity of MGAT2 and a compound capable of inhibiting the activity of MGAT2. It is further another object to provide a method for detecting a disease induced by abnormal lipid metabolism based on the expression level or activity of MGAT2. A method for screening of a compound by using a gene-modified non-human mammal having the artificially inhibited expression of MGAT2 gene and a cell thereof enable to prevent or treat a disease induced by abnormal lipid metabolism. Also a screening of a compound capable of inhibiting or enhancing the function of MGAT2 enables to prevent or treat a disease induced by abnormal lipid metabolism.
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申请公布号 |
US2010074888(A1) |
申请公布日期 |
2010.03.25 |
申请号 |
US20070525410 |
申请日期 |
2007.11.30 |
申请人 |
MERCK & CO., INC. |
发明人 |
ARAGANE KATSUMI;OHBUCHI KTSUYA;TAMAI YOSHITAKA;HARADA NAOMOTO;MURAI NAOMI;ITO YOSHIKI;KUSUNOKI JUN;TOKUSHIMA YUKINA;MARUYAMA TAKAHARU |
分类号 |
A61K39/395;A01K67/027;A61K31/7052;A61K35/00;A61K36/00;A61K38/16;A61P3/06;C12Q1/02;G01N33/50 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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