| 摘要 |
PROBLEM TO BE SOLVED: To provide a novel process for producing nifedipine at a high purity in a high yield and in a short reaction time, the process providing nifedipine which should be used directly as an active compound in a medicament with no additional purification operations. SOLUTION: The process for producing the nifedipine comprises a step of allowing methyl 2-(2-nitrobenzylidene)acetoacetate to react with methyl 3-aminocrotonate in at least one 2-3C alkanol as a solvent; the reaction is performed at a temperature of 70 to 110°C. The reaction is performed at a temperature preferably of 75 to 95°C, particularly preferably, about 85°C in methanol. COPYRIGHT: (C)2010,JPO&INPIT
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