<p>Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics of drugs that undergo in vivo degradation by cytochrome P450 enzymes. Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Specifically, methods of inhibiting metabolic degradation of atazanavir sulphate for administering to a patient suffering from HIV infection are disclosed.</p>
申请公布号
WO2010033614(A1)
申请公布日期
2010.03.25
申请号
WO2009US57183
申请日期
2009.09.16
申请人
SEQUOIA PHARMACEUTICALS;LUDTKE, DOUGLAS;DAGGER, RAYMOND