发明名称 |
METHOD OF MODELLING CHRONIC NEPHROTOXIC GLOMERULONEPHRITIS IN EXPERIMENT |
摘要 |
FIELD: medicine. ^ SUBSTANCE: invention concerns experimental medicine, and can be used for modelling chronic nephrotoxic glomerulonephritis in experiment. That is ensured by introduction of suspension of nephritic antigen to a pedigreeless white rat. Then it is followed with immunisation of a porpoise with a prepared suspension of nephritic antigen with Freund's complete adjuvant. Nephrotoxic serum is prepared. Then nephrotoxic serum is introduced intraperitoneally to a predigreeless white rat. The introduction is scheduled: 2 dosages intraperitoneally once a day every 24 hours at 100 mcl of nephrotoxic serum per 100 g of the animal's weight. ^ EFFECT: method enables to simplify modelling chronic nephrotoxic nephritis, to reduce cost price of the technique, to create a reproduced model for chronic nephrotoxic nephritis. ^ 3 ex |
申请公布号 |
RU2384893(C1) |
申请公布日期 |
2010.03.20 |
申请号 |
RU20080142323 |
申请日期 |
2008.10.24 |
申请人 |
GOSUDARSTVENNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "PERMSKAJA GOSUDARSTVENNAJA MEDITSINSKAJA AKADEMIJA IMENI AKADEMIKA E.A. VAGNERA FEDERAL'NOGO AGENTSTVA PO ZDRAVOOKHRANENIJU I SOTSIAL'NOMU RAZVITIJU" |
发明人 |
KOLOMEETS NADEZHDA JUR'EVNA;KOSAREVA POLINA VLADIMIROVNA;AVER'JANOVA NATAL'JA IVANOVNA;CHERESHNEV VALERIJ ALEKSANDROVICH |
分类号 |
G09B23/28 |
主分类号 |
G09B23/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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