发明名称 |
Polynucleotides and Uses Thereof |
摘要 |
The present invention provides an isolated polynucleotide comprising or consisting of the nucleotide sequence encoding the G protein of human respiratory syncytial virus (RSV), wherein the nucleotide sequence is codon optimised for expression in mammalian cells and wherein the polynucleotide provides increased expression of the G protein in mammalian cells relative to expression of the wildtype RSV-G gene. Preferably, the polynucleotide comprises or consists of the nucleotide sequence of SEQ ID NO:2. Further aspects of the invention provide pharmaceutical compositions, in particular vaccines, for use in methods of immunising a subject against RSV infection.
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申请公布号 |
US2010068226(A1) |
申请公布日期 |
2010.03.18 |
申请号 |
US20080523342 |
申请日期 |
2008.01.18 |
申请人 |
TAYLOR GERALDINE;BEMBRIDGE GARY |
发明人 |
TAYLOR GERALDINE;BEMBRIDGE GARY |
分类号 |
A61K39/155;A61K31/7088;A61P31/12;A61P37/04;C07H21/04;C12N5/07;C12N5/071;C12N5/10;C12N15/09;C12N15/74 |
主分类号 |
A61K39/155 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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