发明名称 |
PEPTIDES AND THEIR DERIVED TYPE APL OF THE HSP60 AND PHARMACEUTICAL COMPOSITIONS |
摘要 |
The invention relates to peptides of the 60-kDa human heat shock protein, which form epitopes for T-cells, as well as peptides derived therefrom, which are modified at the contact sites with the MHC molecule and which can be used to induce peripheral tolerance mechanisms, in particular mechanisms that induce anergy or mechanisms that are mediated by regulatory T-cell clones in patients with rheumatoid arthritis. The invention also relates to pharmaceutical compositions which comprise such peptides and which are intended for the treatment of rheumatoid arthritis.
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申请公布号 |
KR20100028645(A) |
申请公布日期 |
2010.03.12 |
申请号 |
KR20107001135 |
申请日期 |
2005.09.22 |
申请人 |
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA |
发明人 |
DOMINGUEZ HORTA MARIA DEL CARMEN;PADRON PALOMARES GABRIEL RAMON;LOPEZ MARIN NELIA;LORENZO PEREZ NORAILYS;BARBERA BEANCOURT ARIANA;HERNANDEZ GARCIA ARIADNA;MORERA CORDOVA VIVIAN;COSME DIAZ CARELIA;MERINO GARCIA NELSON J.;VAZQUEZ BONACHEA ARIEL;SUAREZ ALBA JOSE |
分类号 |
C07K14/47;A61P19/02 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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