ANIMAL MODEL FOR STUDYING ANGIOGENESIS AND LYMPHANGIOGENESIS IN VIVO

摘要

The present invention applies to the field of molecular biology and biotechnology and relates to a genetically modified non-human mammal, the cells of which incorporate the IRES-EGFP-luciferase construct in the 3'UTR region of the Flt4 gene, which is capable of reporting the expression of the Flt4 gene with a pattern identical to that of expression of the VEGFR-3 receptor. Said non-human mammal is useful in the study and evaluation of the progression of diseases that involve lymphangiogenesis, angiogenesis and/or inflammation, and also for the testing of drugs that aim to modulate said processes and therefore for the development of anti-angiogenic, anti-tumour and antimetastatic therapies.