发明名称 |
SUBSTITUTED HETEROCYCLIC MERCAPTOSULFONAMIDE METALLOPROTEASE INHIBITORS |
摘要 |
The present invention generally relates to substituted heterocyclic mercaptosulfonamide compounds, precursors, and derivatives as well as methods for the preparation of and pharmaceutical compositions comprising these compounds. These compounds are designed to be potent selective inhibitors of matrix metalloproteinases (MMPs), including, for example, gelatinases, collagenases, matrilysins, metalloelastase, stromelysin, and membrane-type 1 matrix metalloproteinase. These inhibitors may be used for the control of physiological and pathological processes and disease conditions in which MMPs are believed to play significant functions. |
申请公布号 |
WO2010028051(A2) |
申请公布日期 |
2010.03.11 |
申请号 |
WO2009US55742 |
申请日期 |
2009.09.02 |
申请人 |
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;SCHWARTZ, MARTIN A.;JIN, YONGHAO;SANG, QING-XIANG (AMY) |
发明人 |
SCHWARTZ, MARTIN A.;JIN, YONGHAO;SANG, QING-XIANG (AMY) |
分类号 |
C07D207/327;A61K31/415;A61P35/00;C07D207/16;C07D237/02;C07D237/12;C07D265/06 |
主分类号 |
C07D207/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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