| 发明名称 |
BICYCLIC COMPOUND, PRODUCTION AND USE THEREOF |
| 摘要 |
<p>The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula:
wherein, R 1 is a 5- to 6-membered ring group which may be substituted; X 1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X 2 is a bivalent group of 1 to 4 atoms; Z 1 is a bivalent cyclic ring group or the like; Z 2 is a bond or the like; and R 2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.</p> |
| 申请公布号 |
EP1423376(B1) |
申请公布日期 |
2010.03.10 |
| 申请号 |
EP20020762751 |
申请日期 |
2002.08.07 |
| 申请人 |
TOBIRA THERAPEUTICS, INC. |
发明人 |
SHIRAISHI, MITSURU;BABA, MASANORI;AIKAWA, KATSUJI;KANZAKI, NAOYUKI;SETO, MASAKI;IIZAWA, YUJI |
| 分类号 |
C07D313/20;C07D403/12;A61K31/335;A61K31/395;A61K31/4178;A61K31/4196;A61K31/427;A61K31/472;A61K31/496;A61K31/513;A61K31/536;A61K31/5513;A61K31/7072;A61K31/708;A61K45/00;A61P9/10;A61P13/12;A61P29/00;A61P31/18;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07D225/06;C07D403/14;C07D405/12;C07D405/14;C07D407/12 |
主分类号 |
C07D313/20 |
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