CYCLOPEPTIDE DERIVATIVES WITH ANTI-INTEGRIN ACTIVITY

摘要

Formula (I) compounds are described c(R₁-Arg-Gly-Asp-R₂) where the meanings of the various groups are as described here below, which are integrin inhibitors, and particularly inhibitors of integrins of the alpha,beta₃ and alpha,beta₅ family, and therefore are useful as medicaments, particularly for the treatment of the diseases underlying abnormal angiogenesis, such as retinopathy, acute renal failure, osteoporosis and metastases. The compounds described herein, when suitably labelled, are also useful as diagnostic agents, especially for the detection of small tumour masses and arterial occlusion events, and as targeted drug vectors.