发明名称 |
Mutations in the BCR-ABL tyrosine kinase associated with resistance to ST1-571 |
摘要 |
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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申请公布号 |
US2010055687(A1) |
申请公布日期 |
2010.03.04 |
申请号 |
US20090381448 |
申请日期 |
2009.03.11 |
申请人 |
SAWYERS CHARLES L;GORRE MERCEDES E;SHAH NEIL PRAVIN;NICOLL JOHN |
发明人 |
SAWYERS CHARLES L.;GORRE MERCEDES E.;SHAH NEIL PRAVIN;NICOLL JOHN |
分类号 |
C12N15/09;C12Q1/68;A61K31/505;A61K31/519;A61K38/17;A61P35/00;C07D239/42;C07D471/04;C07K14/82;C12N9/12;C12Q1/48;G01N33/53;G01N33/574 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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