2-BENZYLSULFANYL-BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF THE DISEASES INDUCED BY THE OVERACTIVATION OF POLY(ADP-RIBOSE)POLYMERASE-1

摘要

PURPOSE: A 2-benzylsulfanyl-benzimidazole-4-carboximide derivative is provided to ensure activity of suppressing poly(ADP-ribose)polymerase-1-(PARP-1) and to prevent or treat diseases caused by over-activation of the PARP-1. CONSTITUTION: A 2-benzylsulfanyl-benzimidazole-4-carboximide derivative is denoted by chemical formula 1. The 2-benzylsulfanyl-benzimidazole-4-carboximide derivative is prepared by performing alkylation of a compound of chemical formula 2 with a compound of chemical formula 3 at room temperature to boiling point under the presence of basic catalyst. The catalyst is carbonate, hydroxise, hydride, alkoxide, triethylamine, or pyridine. A pharmaceutical composition for preventing or treating diseases caused by over-activation of poly(ADP-ribose)polymerase-1(PARP-1) contains the 2-benzylsulfanyl-benzimidazole-4-carboximide derivative of chemical formula 1 or its pharmaceutically acceptable salt as an active ingredient.