2-SULFANYL-BENZIMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT FOR THE PREVENTION AND TREATMENT OF THE DISEASES INDUCED BY THE OVERACTIVATION OF POLY(ADP-RIBOSE)POLYMERASE-1
摘要
PURPOSE: A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is provided to repair damaged DNA and suppress poly(ADP-ribose)polymerase-1(PARP-1) which is an enzyme causing cell damage and apoptosis. CONSTITUTION: A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is denoted by chemical formula 1. A 2-sulfanyl-benzimidazole-4-carboximidazole derivative is prepared by performing alkylation of a compound of chemical formula 2 and a compound of chemical formula 3. A basic catalyst is used in the preparation. The basic catalyst is carbonate including sodium carbonate, potassium carbonate, or cesium carbonate; hydroxide including potassium hydroxide or sodium hydroxide; hydride including sodium hydride; alkoxide including sodium methoxide and sodium t-butoxide; triethylamine; or pyridine. A pharmaceutical composition for preventing or treating diseases caused by over-activation contains the 2-sulfanyl-benzimidazole-4-carboximidazole derivative or its pharmaceutically acceptable salt as an active ingredient.
申请公布号
KR20100022618(A)
申请公布日期
2010.03.03
申请号
KR20080081209
申请日期
2008.08.20
申请人
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
发明人
YI, KYU YANG;LEE, SUN KYUNG;KIM, NACK JEONG;SUH, JEE HEE;LIM, CHAE JO;LEE, BYUNG HO;OH, KWANG SEOK;SEO, HO WON;YOO, SUNG EUN;LEE, KYUNG HEE;KIM, YOU SUN