Nucleic acids and polypeptides that are useful in controlling neuronal regeneration

摘要

The present invention relates to methods for promoting regeneration response of peripheral and central nervous systems in mammals in need of such biological effects. The methods comprise altering the activity or steady state level of specific polypeptides that control regeneration of injured or degenerated neuronal cells. Preferably the activity or steady state level of specific polypeptides is altered by introducing nucleic acids to increase or decrease expressing of the polypeptides. These are useful in or suffering from neurodegenerative disorders.