发明名称 |
Alpha-1-Antitrypsin Variants and Uses Thereof |
摘要 |
The subject invention is directed to novel polynucleotides and polypeptides comprising SEQ ID NOs: 1 and 2. Also provided arc fragments these polypeptides. The polynucleotides and polypeptides disclosed herein have been isolated from the liver cells (hepatocytes) of end stage liver failure patients and appear to be associated with a poor prognosis for these patients as relates to liver function. The subject application provides therapeutic methods and reagents for treating livers in which the polynucleotide and polypeptide of SEQ ID NO: 1 and 2 are identified as well as diagnostic methods and reagents for identifying individuals at risk of liver failure. Finally, the subject invention also provides a system of the classification, revision or reordering of a classification system of liver transplant patients.
|
申请公布号 |
US2010048680(A1) |
申请公布日期 |
2010.02.25 |
申请号 |
US20080522958 |
申请日期 |
2008.01.11 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC. |
发明人 |
LIU CHEN;DONG HUI-JIA |
分类号 |
A61K31/7088;A61P1/16;A61P37/06;C12N5/071;C12Q1/68;G01N33/53 |
主分类号 |
A61K31/7088 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|