The present invention relates to antibodies and antigen-binding fragments thereof, immunogenic peptide(s), and siRNA molecules which are capable of inhibiting neovascularization and/or angiogenesis and endothelial cell proliferation. The invention relates to antibodies and antigen-binding fragments thereof with specificity towards the metalloprotease domain of ADAM 15 and to immunogenic peptide(s) that elicits such antibodies. The invention also relates to compositions and kits comprising the antibodies and immunogenic peptide(s) of the invention, as well as methods and uses of the antibodies and antigen-binding fragments thereof and immunogenic peptide(s), as well as siRNA molecules.
申请公布号
WO2009118660(A3)
申请公布日期
2010.02.25
申请号
WO2009IB05613
申请日期
2009.03.24
申请人
RAHMAN, SALMAN;PATEL, YATIN;GERHARDT, HOLGER;LUNDKVIST, ANDREA, EMMA
发明人
RAHMAN, SALMAN;PATEL, YATIN;GERHARDT, HOLGER;LUNDKVIST, ANDREA, EMMA