Intranasal vaccine for use against disease caused by enterotoxigenic Escherichia coli

摘要

The disclosure relates to an intranasal peptide vaccine for use against infection caused by enterotoxigenic Escherichia coli (ETEC), containing a common linear protein epitope known as CLE which is recognized by sera of patients infected with the bacteria and which is associated with a mucosal adjuvant comprising cholera toxin subunit B, known as CTB. The disclosure relates to a peptide containing twenty amino acids, which is located in the linear sequence of the CFA/I fimbria of enterotoxigenic Escherichia coli.