The present invention relates to an alternative strategy for expressing the antisense sequence of a miRNA. This system allows for continuous production of the antisense sequence and subsequently complete knockdown of the targeted miRNA.
申请公布号
WO2009132351(A9)
申请公布日期
2010.02.18
申请号
WO2009US41825
申请日期
2009.04.27
申请人
UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY;ABDELLATIF, MAHA;VATNER, STEPHEN, F.;VATNER, DOROTHY, E.;SADOSHIMA, JUNICHI