| 摘要 |
The present invention provides a method of polyubiquitinating a nucleophosmin comprised of reacting the nucleophosmin in vitro or in vivo with BRCA1-BARD1. The present invention also provides a method of inhibiting polyubiquitination of nucleophosmin comprised of phosphorylating BARD1 using CDK2-cyclin E and/or CDK2-cyclin A.
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