<p>Disclosed herein are compounds and methods for decreasing PrP and preventing, ameliorating, or treating a prion disease or conformational neurodegenerative disorder, in an individual in need thereof. Examples of disease conditions that can be ameliorated with the administration of antisense compounds targeted to PrP include Creutzfeldt- Jakob disease (CJD); variant Creutzfeldt- Jakob Disease (vCJD); Gerstmann-Straussler-Scheinker syndrome; fatal familial insomnia; kuru; Bovine Spongiform Encephalopathy (BSE), e.g. "mad cow disease"; Chronic Wasting Disease (CWD); scrapie; transmissible mink encephalopathy; feline spongiform encephalopathy; ungulate spongiform encephalopathy; Alzheimer's disease; Parkinson's disease; Huntington's disease; and Amyotrophic Lateral Sclerosis (ALS).</p>
申请公布号
WO2010019270(A1)
申请公布日期
2010.02.18
申请号
WO2009US04680
申请日期
2009.08.14
申请人
HUNG, GENE;ISIS PHARMACEUTICALS, INC.;BENNETT, C., FRANK