发明名称 |
PURINE NUCLEOSIDE PHOSPHORYLASE AS ENZYMATIC ACTIVATOR OF NUCLEOSIDE PRODRUGS |
摘要 |
A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(²-D-arabinofuranosyl)-2-fluoroadenine (F-araA). |
申请公布号 |
CA2946532(A1) |
申请公布日期 |
2010.02.18 |
申请号 |
CA20092946532 |
申请日期 |
2009.08.17 |
申请人 |
THE UAB RESEARCH FOUNDATION;SOUTHERN RESEARCH INSTITUTE |
发明人 |
PARKER, WILLIAM B.;SORSCHER, ERIC J. |
分类号 |
A61K38/45;A61K31/7076;A61P31/12;A61P35/00 |
主分类号 |
A61K38/45 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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