发明名称 |
Compounds and methods for assessment of microsatellite instability (MSI) status |
摘要 |
The present invention provides a method for assessment of the Microsatellite Instability (MSI) status of medically relevant conditions associated with MSI phenotype such as e.g. neoplastic lesions. The method is based on the analysis of a monomorphic T25 (CAT25) mononucleotide repeat located in the 3'-UTR of the Caspase 2 (CASP2) gene. Based on the determination of the length of the named mononucleotide repeat the presence or absence of MSI may be assessed. Determination of the length is performed in a single PCR procedure. Alternatively an enhanced assessment could be performed by combining the CAT25 marker with further markers such as BAT25 and BAT26 in a single multiplex PCR process.
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申请公布号 |
US7662595(B2) |
申请公布日期 |
2010.02.16 |
申请号 |
US20050576597 |
申请日期 |
2005.10.19 |
申请人 |
MTM LABORATORIES, AG |
发明人 |
FINDEISEN PETER;MERX SABINE;KLOOR MATTHIAS;DOEBERITZ MAGNUS VON KNEBEL |
分类号 |
C12Q1/68;C07H21/02;C07H21/04;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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主权项 |
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地址 |
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