发明名称 |
Chimeric antibody against tumor associated antigens and its use in diagnosing tumors |
摘要 |
The invention relates to murine monoclonal antibodies (MAbs), A, B, C and D, which are directed against tumor-associated antigens. The nearly complete nucleotide sequences of the V genes of these MAbs are described, so that the relevant variable domains can be put together to give chimeric MAbs, or "humanized" MAbs are obtained by inserting the hypervariable regions (complementarity determining regions=CDR) into a human MAb framework. Antibody constructs of this type can be employed in human therapy and in vivo diagnosis without the disadvantages observed with murine MAbs.
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申请公布号 |
US7662383(B2) |
申请公布日期 |
2010.02.16 |
申请号 |
US20080068545 |
申请日期 |
2008.02.07 |
申请人 |
AVENTIS PHARMA DEUTSCHLAND GMBH |
发明人 |
BOSSLET KLAUS;SEEMANN GERHARD;SEDLACEK HANS HARALD;AUERBACH BERNHARD |
分类号 |
A61K39/395;A61K38/00;A61K47/00;A61K47/48;A61K49/00;A61K51/00;A61K51/10;C07K16/00;C07K16/30;C07K19/00;C12P21/08;G01N33/577 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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