| 摘要 |
The present invention relates to novel pharmaceutical formulations for the prolonged release of active principle (AP), which make it possible to release the AP over a prolonged duration of several days, or even several weeks. The invention relates, in a first aspect, to a liquid formulation, comprising at least one active principle (AP) and an aqueous suspension, based on colloidal particles of a polymer (PO), characterized in that it satisfies the following four conditions: (a) the polymer (PO) is a polyamino acid comprising glutamic residues,-certain glutamic residues bearing a pendant cationic group (CG), the cationic groups being identical to or different from one another,-other glutamic residues bearing a pendant hydrophobic group (HG), said hydrophobic groups (HG) being identical to or different from one another; (b) the value pHf of the pH of said formulation is between 3.0 and 6.5; (c) for the value pHf of the pH, the polymer (PO) forms a colloidal solution which combines spontaneously and non-covalently with the active principle (AP); (d) 1 ml of said formulation precipitates during mixing with a volume of 1 ml of a test buffer solution T. The invention also relates to the process for preparing this formulation and a process for preparing medications.
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