| 摘要 |
The invention relates to a process for the optical resolution of a dibenzo[b,d]azepinone derivative of the formula (II) wherein Ris hydrogen or halogen and Rhas the meaning of C-alkyl optionally substituted with C-cycloalkyl or benzyl which is optionally substituted with C-alkoxy to obtain a (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one of the formula (I) wherein Ris as above. The (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-ones of formula (I) can be used as chiral building blocks for the preparation of malonamide derivatives which have the potential to act as γ-secretase inhibitors and therefore may be useful in the treatment of Alzheimer's disease and cancer.
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