| 发明名称 |
REPLICATION-COMPETENT ANTI-CANCER VECTORS |
| 摘要 |
Novel vectors which are replication competent in neoplastic cells and which overexpress an adenovirus death protein are disclosed. Some of the disclosed vectors are replication-restricted to neoplastic cells or to neoplastic alveolar type II cells. Compositions and methods for promoting the death of neoplastic cells using these replication-competent vectors are also disclosed.
|
| 申请公布号 |
US2010034776(A1) |
申请公布日期 |
2010.02.11 |
| 申请号 |
US20090561016 |
申请日期 |
2009.09.16 |
| 申请人 |
WOLD WILLIAM S M;TOTH KAROLY;DORONIN KONSTANTIN;TOLLEFSON ANN E |
发明人 |
WOLD WILLIAM S.M.;TOTH KAROLY;DORONIN KONSTANTIN;TOLLEFSON ANN E. |
| 分类号 |
A61K35/76;C12N15/09;A61K31/711;A61K45/00;A61K48/00;A61P31/12;A61P35/00;A61P43/00;C07K14/075;C12N5/07;C12N5/10;C12N7/00;C12N15/00;C12N15/861 |
主分类号 |
A61K35/76 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
