It has been discovered that the uptake of anionic charged species into cells can be enhanced by noncovalently associating such species with specifically modified forms of cyclodextrin. The invention modified forms of cyclodextrin form well defined stoichiometric complexes with anionic charged molecules. This discovery enables one to produce various compositions containing anionic charged molecules and facilitates methods for enhancing the cellular uptake of double-stranded or hairpin nucleic acid.
申请公布号
WO2010017328(A2)
申请公布日期
2010.02.11
申请号
WO2009US52898
申请日期
2009.08.05
申请人
RGO BIOSCIENCES LLC;CHUCHOLOWSKI, ALEXANDER;HERMANN, THOMAS;AYIDA, BENJAMIN;WANG, TINGMIN;KHASANOV, ALISHER
发明人
CHUCHOLOWSKI, ALEXANDER;HERMANN, THOMAS;AYIDA, BENJAMIN;WANG, TINGMIN;KHASANOV, ALISHER